Persons with chronic pain or painful life threatening illness often suffer from depression,insomnia,anxiety,stress,anger,substance/alcohol abuse and even hopelessness and suicide. A further problem is persons with chronic pain or illness often feel isolated because persons often do not know how to interact with them because they cannot relate to their problems even if they understand it would be very difficult if not horrible to always be in chronic pain or a painful life threatening illness. Based on long term experience with persons on both sides of this situation,the following are recommendations meant to help persons interact sensitively and effectively with those in chronic pain or chronically ill: 1.Be open and honest. 2.Listen to how their condition impacts them both physically and emotionally. 3.Be tolerant to a possible uncharacteristic negative and even angry mood. 4.Make sure the meeting is not about you and your feelings or pains. 5.Let them know you care and will be helpful any way possible. 6.Do not compare their situation with someone else. 7.Use active listening to fully understand their feelings. 8,Read up on the effects of chronic pain and illness on someone both psychologically and physically.