Endometriosis is painful and draining.
A 2021 NIH study: The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial followed 60 women
Background: Endometriosis is a chronic and estrogen-dependent pelvic inflammatory disease, which may have various causes, such as oxidative stress. Dysmenorrhea, dyspareunia, and pelvic pain are well-known symptoms of endometriosis. The present clinical trial assessed the role of supplementation with antioxidant vitamins on the indices of oxidative stress as well as the severity of pain in women with endometriosis.
These women were between the ages of 15-65.
These were women who experienced pelvic pain and diagnosed with endometriosis.
The women were given 1000 mg of vitamin c, and 800IUs of vitamin E per day against the control group with a placebo.
This was a triple blind study meaning subjects, investigators and statistical analyzers were not given access to any information apart from the results at the end. It was highly quality study.
Findings: Oxidative stress greatly reduced.
Explanation: Estrogen is a key agent in the rapid growth or reproduction of new cells, of uterine tissues, it’s capacity to disrupt thyroid and progesterone signaling can also spill over to increasing β-Glucuronidase (an estrogen stimulating/promoting agent) and increases oxidative stress, wasting vitamin C and vitamin e.
Stress wastes vitamin C and E.
Results: Following treatment with vitamin C and vitamin E, we found a significant reduction in MDA and ROS compared with the placebo group. In the study the most positive finding is that pelvic pain markers substantially and significantly.
Conclusions: The present findings support the potential role of antioxidants in the management of endometriosis. The intake of vitamin C and vitamin E supplements effectively reduced dysmenorrhea severity and improved dyspareunia and severity of pelvic pain.